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Treatment-experienced people
Redefining Expanded Access Programs for patients with MDR-HIV

It is time to create a new paradigm to break the vicious cycle of single drug access that has failed these patients.

Published
04 December 2012
From
GMHC Treatment Issues
HIV treatment
New fixed-dose combination pills measure up to Atripla - corrected version*

Several studies, or updates of studies, comparing newer against older drug regimens were presented at the Eleventh International Congress on Drug Therapy in HIV Infection last week.

Published
20 November 2012
By
Gus Cairns
Changing treatment
Raltegravir-resistant HIV stays susceptible to dolutegravir in lab

HIV resistant to the integrase inhibitor raltegravir and isolated from patients taking a failing raltegravir regimen remained largely susceptible to the integrase inhibitor dolutegravir in phenotypic susceptibility testing. Raltegravir-resistant virus carrying a mutation at position Q148 had more reduced susceptibility to dolutegravir than isolates with other raltegravir mutations.

Published
13 November 2012
From
International AIDS Society
Resistance
The genetics of HIV-1 resistance

New research has examined the genetic footprint that drug resistance causes in HIV and found compensatory polymorphisms that help the resistant virus to survive.

Published
08 October 2012
From
Science Daily
How transmission occurs
In heterosexuals, transmitted HIV strains often resemble original infecting virus

A new study has found that even though HIV diversifies widely within infected individuals over time, the virus strains that ultimately are passed on through heterosexual transmission often resemble the strain of virus that originally infected the transmitting partner. Learning the characteristics of these preferentially transmitted HIV strains may help advance HIV prevention efforts, particularly with regard to an HIV vaccine, according to the scientists who conducted the study.

Published
25 September 2012
From
Eurekalert Inf Dis
Resistance
Mutation breaks HIV's resistance to drugs

The human immunodeficiency virus (HIV) can contain dozens of different mutations, called polymorphisms. In a recent study an international team of researchers found that one of those mutations, called 172K, made certain forms of the virus more susceptible to treatment. Soon, doctors will be able to use this knowledge to improve the drug regimen they prescribe to HIV-infected individuals.

Published
14 September 2012
From
Science Daily
New and experimental HIV treatments
Long-acting fusion inhibitor albuvirtide looks promising in early studies

A new fusion inhibitor that prevents HIV entry into cells showed potent antiviral activity in early clinical studies and has a long half-life, suggesting it may be

Published
11 September 2012
By
Liz Highleyman
HIV prevention policy
'Test And Treat' Strategy For Curbing HIV Draws Questions

Test and treat sounds good on paper, but some doctors and policymakers have doubts about its feasibility on a large scale.

Published
11 September 2012
From
NPR
Resistance
Decline in transmitted resistance to ARVs in UK leveled off in 2009

Rates of HIV resistant to antiretrovirals (ARVs) fell substantially from 2002 through 2007 among untreated people infected with subtype B virus within the United Kingdom. But then the decline leveled off and may have rebounded slightly through 2009.

Published
03 September 2012
From
International AIDS Society
Resistance
Anti-HIV drug simulation offers 'realistic' tool to predict drug resistance and viral mutation

Pooling data from thousands of tests of the antiviral activity of more than 20 commonly used anti-HIV drugs, AIDS experts at Johns Hopkins and Harvard universities have developed what they say is the first accurate computer simulation to explain drug effects.

Published
03 September 2012
From
Eurekalert Medicine & Health
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